Guvacoline (hydrochloride)

Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors[1][2].

Product Specifications

CAS Number

[6197-39-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/guvacoline-hydrochloride.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CCCNC1)OC.[H]Cl

Molecular Formula

C7H12ClNO2

Molecular Weight

177.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiao Wu, et al. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra. J Plant Res. 2019 Jul;132 (4) :531-540.|[2]M Wolf-Pflugmann, et al. Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung. 1989 May;39 (5) :539-44.