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Clomipramine-d3 (hydrochloride)

Clomipramine-d3 (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively[1][2].

Product Specifications

CAS Number

1398065-86-5

Product Name Alternative

Chlorimipramine-d3 (hydrochloride) ; G-34586-d3 (hydrochloride) ; NSC-169865-d3 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H361, H400, H410

Target

Dopamine Receptor; Serotonin Transporter

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.98

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC1=CC2=C(CCC3=C(N2CCCN(C)C([2H])([2H])[2H])C=CC=C3)C=C1.Cl

Molecular Formula

C19H21D3Cl2N2

Molecular Weight

354.33

Precautions

H302, H361, H400, H410

References & Citations

[1] Owens, M.J., et al., Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther, 1997. 283 (3) : p. 1305-22.|[2]McTavish, D. and P. Benfield, Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs, 1990. 39 (1) : p. 136-53.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

D3 Receptor

Available Sizes

Frequently Asked Questions

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