S-Propargylcysteine
Product Specifications
UNSPSC Description
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H2S-releasing compound. S-Propargylcysteine reduces Ca2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties[1][2].
Target Antigen
MDM-2/p53; STAT
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-propargylcysteine.html
Purity
97.0
Solubility
DMSO : < 1 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Smiles
O=C([C@H](CSCC#C)N)O
Molecular Weight
159.21
References & Citations
[1]Sidhapuriwala JN, et al. Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS One. 2012;7(3):e32574.|[2]Wen YD, et al. The Pharmacological Effects of S-Propargyl-Cysteine, a Novel Endogenous H2S-Producing Compound. Handb Exp Pharmacol. 2015;230:325-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W001538/S-Propargylcysteine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W001538/S-Propargylcysteine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3262-64-4
Available Sizes
Curated Selection
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