2-Chloro-3-deazaadenosine
2-Chloro-3-deazaadenosine is agonists for adenosine receptor, with Kis of 0.3, 0.08, 25.5 and 1.9 μM, for A1, A2A, A2B, and A3 receptors, respectively[1].
Product Specifications
CAS Number
[40656-71-1]
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-chloro-3-deazaadenosine.html
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=CC(Cl)=NC(N)=C3N=C2)O1
Molecular Formula
C11H13ClN4O4
Molecular Weight
300.70
References & Citations
[1]Linden J, et al., Characterization of human A (2B) adenosine receptors: radioligand binding, western blotting, and coupling to G (q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56 (4) :705-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)
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