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2-Chloro-3-deazaadenosine

2-Chloro-3-deazaadenosine is agonists for adenosine receptor, with Kis of 0.3, 0.08, 25.5 and 1.9 μM, for A1, A2A, A2B, and A3 receptors, respectively[1].

Product Specifications

CAS Number

[40656-71-1]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-chloro-3-deazaadenosine.html

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=CC(Cl)=NC(N)=C3N=C2)O1

Molecular Formula

C11H13ClN4O4

Molecular Weight

300.70

References & Citations

[1]Linden J, et al., Characterization of human A (2B) adenosine receptors: radioligand binding, western blotting, and coupling to G (q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56 (4) :705-13.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR) ; Adenosine A3 receptor (A3R)

Available Sizes

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