WIZ degrader 3
WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia[1].
Product Specifications
CAS Number
2839637-72-6
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/wiz-degrader-3.html
Smiles
O=C(NC(CC1)=O)N1C2=NOC3=CC=C(C=C23)CN4C[C@@H](N(CC4)C)C
Molecular Formula
C18H23N5O3
Molecular Weight
357.41
References & Citations
[1]BECKWITH IREJ, et al. Benzisoxazole derivatives and uses thereof. WO2022195355A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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