CP-24879 (hydrochloride)

CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].

Product Specifications

CAS Number

[10141-51-2]

Product Name Alternative

21-desDFZ-d5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cp-24879-hydrochloride.html

Purity

99.59

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=CC=C(OCCC(C)C)C=C1.Cl

Molecular Formula

C11H18ClNO

Molecular Weight

215.72

Precautions

H315, H319, H335

References & Citations

[1]Obukowicz MG, et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol. 1998 Apr 1;55 (7) :1045-58.|[2][2]López-Vicario C, et al. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb;63 (2) :344-55.|[3][3]Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117 (51) :32433-32442.