TGFβRII-IN-3

TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC50 = 4.1 μM) . TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research[1].

Product Specifications

CAS Number

[2351149-20-5]

UNSPSC

12352005

Target

TGF-beta/Smad; TGF-β Receptor

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tgfβri-in-7.html

Purity

99.51

Solubility

DMSO : 4.17 mg/mL (ultrasonic)

Smiles

O=C(N(CC1=CC=CC(C2=CC=C(C(F)(F)F)C=C2)=C1)C)C3=C(C)NC4=C3C(CC(C)(C4)C)=O

Molecular Formula

C27H27F3N2O2

Molecular Weight

468.51

References & Citations

[1]Längle D, et al.Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives. ACS Pharmacol Transl Sci. 2024 Mar 21;7 (4) :1069-1085.