(E/Z) -Zotiraciclib (citrate)

(E/Z) -Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor[1].

Product Specifications

CAS Number

[1204918-73-9]

Product Name Alternative

(E/Z) -TG02 (citrate) ; (E/Z) -SB1317 (citrate)

UNSPSC

12352005

Target

CDK; FLT3; JAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-zotiraciclib-citrate.html

Purity

99.83

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC(C(O)=O)(CC(O)=O)CC(O)=O.CN1CC2=CC(NC3=NC(C4=CC(OCC/C=C/C1)=CC=C4)=CC=N3)=CC=C2

Molecular Formula

C29H32N4O8

Molecular Weight

564.59

References & Citations

[1]William AD, et al. Discovery of kinase spectrum selective macrocycle (16E) -14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1 (2,6) .1 (8,12) ]heptacosa-1 (25),2 (26),3,5,8 (27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55 (1) :169-196.