(E/Z)-Zotiraciclib (citrate)
Product Specifications
UNSPSC Description
(E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor[1].
Target Antigen
CDK; FLT3; JAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-zotiraciclib-citrate.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OC(C(O)=O)(CC(O)=O)CC(O)=O.CN1CC2=CC(NC3=NC(C4=CC(OCC/C=C/C1)=CC=C4)=CC=N3)=CC=C2
Molecular Weight
564.59
References & Citations
[1]William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55(1):169-196.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15166B/E-Z-Zotiraciclib-citrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15166B/E-Z-Zotiraciclib-citrate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1204918-73-9
Available Sizes
Curated Selection
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