PROTAC BcI-2/BcI-xI Degrader-1
Product Specifications
UNSPSC Description
PROTAC BcI-2/BcI-xI Degrader-1 (15) is a PROTAC based BcI-2/BcI-xI degrader (Red: BcI-2/BcI-xI inhibitor (HY-158677), black: linker, Blue: E3 ligase ligand)[1].
Target Antigen
Bcl-2 Family; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-bci-2-bci-xi-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=S(NC(C1=CC=C(N2[C@@](CO3)([H])CN(CC2)CC4=C(C5=CC=C(C=C5)Cl)CCC(C)(C4)C)C3=C1)=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCN(CC8)C(CCCCCC(N[C@@H](C(C)(C)C)C(N9[C@@H](C[C@H](C9)O)C(NCC%10=CC=C(C%11=C(N=CS%11)CCO%12)C%12=C%10)=O)=O)=O)=O)=O
Molecular Weight
1584.35
References & Citations
[1]Dongping, et al. Chimeric compound used for targeted degradation of bcl-2 protein, preparation method therefor, and pharmaceutical application thereof. Patent. WO2024067818A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158551/PROTAC-BcI-2-BcI-xI-Degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158551/
Clinical Information
No Development Reported
CAS Number
3034200-49-9
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