Ethacizine (hydrochloride)
Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].
Product Specifications
CAS Number
57530-40-2
Product Name Alternative
Ethacizin; NIK-244
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ethacizine-hydrochloride.html
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC)NC(C=C1N2C(CCN(CC)CC)=O)=CC=C1SC3=C2C=CC=C3.[H]Cl
Molecular Formula
C22H28ClN3O3S
Molecular Weight
449.99
References & Citations
[1]Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56 (1) :1-12.|[2]Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98 (3) :827-32.Med Chem. 2019 Nov 6:115132.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
P003-410-500 1x 500 µL
ExoBriteTM 410/450 CD9 Flow Antibody (100 tests)
Sign In for Pricing
View Details 
![RPB3 Recombinant Rabbit Monoclonal Antibody [JE34-81]](https://cdn.genprice.uk/products/992/68dd1c90061270361ea8286b/imageurl/ha722448.webp)
HA722448 100 µL
RPB3 Recombinant Rabbit Monoclonal Antibody [JE34-81]
Sign In for Pricing
View Details 