P-Ethynylphenylalanine
P-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[278605-15-5]
Product Name Alternative
4-Ethynyl-L-phenylalanine
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-ethynyl-l-phenylalanine.html
Concentration
10mM
Purity
99.93
Solubility
1M HCl : 240 mg/mL (ultrasonic; adjust pH to 1 with HCl) |1M NaOH : 240 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 2.22 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O
Molecular Formula
C11H11NO2
Molecular Weight
189.21
Precautions
H315, H319, H335
References & Citations
[1]Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74 (5) :2067-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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