2'-Aminoacetophenone

2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle[1][2][4].

Product Specifications

CAS Number

[551-93-9]

Product Name Alternative

O-aminoacetophenone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Atg8/LC3; Autophagy; Bacterial; p62

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-aminoacetophenone.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC=CC=C1N)=O

Molecular Formula

C8H9NO

Molecular Weight

135.17

Precautions

H315, H319, H335

References & Citations

[1]Chakraborty A, et al. Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis. mBio. 2023 Apr 25;14 (2) :e0015923.|[2]Scott-Thomas AJ, et al. 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulm Med. 2010 Nov 7;10:56.|[3]Kapsetaki SE, et al. The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies. Nat Commun. 2014 Jul 21;5:4401. |[4]Bandyopadhaya A, et al. Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle. Int J Mol Med. 2016 Apr;37 (4) :867-78.