IDR-1018
IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate) [1][2].
Product Specifications
CAS Number
[1453221-07-2]
UNSPSC
12352209
Target
Antibiotic; Bacterial; Parasite
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/idr-1018.html
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)C(C)C)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O
Molecular Formula
C71H126N26O12
Molecular Weight
1535.93
References & Citations
[1]Hashem Etayash, Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response. J. Med. Chem. 2021, 64, 22, 16854-16863.|[2]Hashem Etayash, et al. Correction to “Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response”. J. Med. Chem. 2022, 65, 3, 2710-2711.|[3]François Niyonsaba, et al. The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions. J Leukoc Biol. 2013 Jul;94 (1) :159-70.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3361/IDR-1018-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3361/
Scientific Category
Peptides
Clinical Information
Phase 1
Curated Selection
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