SAH-EZH2

SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27[1].

Product Specifications

CAS Number

[1453222-26-8]

UNSPSC

12352209

Target

Histone Methyltransferase

Type

Peptides

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sah-ezh2.html

Purity

99.50

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@]1(NC([C@@H](NC([C@](NC([C@@H](NC([C@](C)(CCC/C=C/CCC1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CO)NC([C@@H](NC(C)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)CCCCN)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)C)N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O