Menin-MLL inhibitor 34
Menin-MLL inhibitor 34 (Compound 37) is a selective and potent Menin-MLL inhibitor, with an IC50 of 18.21 nM for Menin. Menin-MLL inhibitor 34 has long-lasting anti-leukemic effects by reducing Menin protein levels and down-regulating MEN1 transcription[1].
Product Specifications
CAS Number
3096376-30-3
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/menin-mll-inhibitor-34.html
Smiles
O=C(N(CC)C(C)C)C1=CC(F)=CC=C1NC2=CN=CN=C2N3CCN(CC4CN(C5=CC=C(S(=O)(C6CN(C(/C=C/CN(C)C)=O)C6)=O)C=C5)C4)C(C)C3
Molecular Formula
C40H54FN9O4S
Molecular Weight
775.98
References & Citations
[1]Luo M, et al. Design and development of a series of 4- (piperazin-1-yl) pyrimidines as irreversible menin inhibitors. Eur J Med Chem. 2024 Sep 30;280:116918.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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