Lycorine

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[2]. Lycorine is also a melanoma vasculogenic inhibitor[3]. Lycorine can be used for the study of prostate cancer and metabolic diseases[2].

Product Specifications

CAS Number

[476-28-8]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Bacterial; Fatty Acid Synthase (FASN) ; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lycorine.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4

Molecular Formula

C16H17NO4

Molecular Weight

287.31

Precautions

H301

References & Citations

[1]Hu M, et al.Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.Oncotarget. 2015 Jun 20;6 (17) :15348-61.|[2]Zu-Guo Zheng, et al. Discovery of a Potent SCAP Degrader That Ameliorates HFD-induced Obesity, Hyperlipidemia and Insulin Resistance via an Autophagy-Independent Lysosomal Pathway. Autophagy. 2020 May 20;1-22.|[3][1].Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012) .