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N-Fmoc-N'- (azido-PEG4) -L-Lysine-PFP ester

N-Fmoc-N'- (azido-PEG4) -L-Lysine-PFP ester is an alkyl/ether and PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Fmoc-N'- (azido-PEG4) -L-Lysine-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-fmoc-n-azido-peg4-l-lysine-pfp-ester.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=C(NCCCC[C@H](NC(OCC1C(C=CC=C2)=C2C3=C1C=CC=C3)=O)C(OC4=C(F)C(F)=C(F)C(F)=C4F)=O)CCOCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C38H42F5N5O9

Molecular Weight

807.76

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers; PEG Linkers

Available Sizes

Curated Selection

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