NH-bis (PEG2-propargyl)

NH-bis (PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH-bis (PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2100306-83-8]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh-bis-peg2-propargyl.html

Purity

95.21

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C#CCOCCOCCNCCOCCOCC#C

Molecular Formula

C14H23NO4

Molecular Weight

269.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562