S49076
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.
Product Specifications
CAS Number
[1265965-22-7]
UNSPSC
12352005
Hazard Statement
H302
Target
C-Met/HGFR; FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/S49076.html
Concentration
10mM
Purity
99.44
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=C(N1CC2=CC3=C(NC(/C3=C\C4=CC(CN5CCOCC5)=CN4)=O)C=C2)SCC1=O
Molecular Formula
C22H22N4O4S
Molecular Weight
438.50
Precautions
H302
References & Citations
[1]Burbridge MF, et al. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol Cancer Ther. 2013 Sep;12 (9) :1749-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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