5-Fluoro-2'-deoxycytidine

5-Fluoro-2'-deoxycytidine (FdCyd), a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of thymidylate synthase inhibitor 5-fluoro-2′-dUMP. 5-Fluoro-2'-deoxycytidine can induce cell cycle arrest in tumor cells through the DNA damage response, and it has anti-tumor activity[1][2][3].

Product Specifications

CAS Number

[10356-76-0]

Product Name Alternative

FdCyd; NSC-48006

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-fluoro-2-deoxycytidine.html

Purity

99.66

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N2C(N=C(N)C(F)=C2)=O)O[C@@H]1CO

Molecular Formula

C9H12FN3O4

Molecular Weight

245.21

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Beumer JH, et, al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin Cancer Res. 2006 Dec 15;12 (24) :7483-91.|[2]Osterman DG, et, al. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12;27 (14) :5204-10.|[3]Zhao Q, et al. Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway. Springerplus. 2012 Dec;1 (1) :65.