Hydroxytanshinone IIA

Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2[1].

Product Specifications

CAS Number

[18887-18-8]

UNSPSC

12352005

Target

Drug Metabolite; VEGFR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hydroxytanshinone-iia.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C=CC3=C1C(O)CCC3(C)C)C(C4=C2OC=C4C)=O

Molecular Formula

C19H18O4

Molecular Weight

310.34

References & Citations

[1]Peng Li, et al. Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20 (5) :815-22.