Elismetrep
Elismetrep (MT-8554) is a TRPM8 antagonist. Elismetrep reduces the frequency of vasomotor symptoms. Elismetrep can be used for study of pain[1][2].
Product Specifications
CAS Number
1400699-64-0
Product Name Alternative
MT-8554
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/elismetrep.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(S(=O)(N(CC2=CC=C(C=C2)OC(F)(F)F)C3=C(C4CC4)C5=CC=CC=C5C=N3)=O)C=C1)O
Molecular Formula
C27H21F3N2O5S
Molecular Weight
542.53
References & Citations
[1]Conklin M, et al. Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause. Ther Adv Reprod Health. 2023 Jun 22;17:26334941231177611. |[2]Weyer AD, et al. Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine. Pharmaceuticals (Basel) . 2017 Mar 30;10 (2) :37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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