Phox-I2
Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].
Product Specifications
CAS Number
353495-22-4
UNSPSC
12352005
Hazard Statement
H302, H315, H335
Target
NADPH Oxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/phox-i2.html
Purity
99.44
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=[N+]([O-])C1=CC(C2NC3=C(C4C2CC=C4)C=C(C=C3)[N+]([O-])=O)=CC=C1
Molecular Formula
C18H15N3O4
Molecular Weight
337.33
Precautions
H302, H315, H335
References & Citations
[1]Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67 (phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19 (2) :228-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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