Phox-I2

Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].

Product Specifications

CAS Number

[353495-22-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H335

Target

NADPH Oxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/phox-i2.html

Purity

99.44

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=[N+]([O-])C1=CC(C2NC3=C(C4C2CC=C4)C=C(C=C3)[N+]([O-])=O)=CC=C1

Molecular Formula

C18H15N3O4

Molecular Weight

337.33

Precautions

H302, H315, H335

References & Citations

[1]Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67 (phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19 (2) :228-42.