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Cephalosporin C zinc salt

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM[1]. Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity[2].

Product Specifications

CAS Number

[59143-60-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Cephalosporin_C_zinc_salt.html

Purity

99.31

Solubility

DMSO : 5 mg/mL (ultrasonic; adjust pH to 3 with 1M HCl) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(OCC1=C(C([O-])=O)N(C([C@H]2NC(CCC[C@@H](N)C([O-])=O)=O)=O)[C@]2([H])SC1)=O.[Zn+2]

Molecular Formula

C16H19N3O8SZn

Molecular Weight

478.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Seamon KJ, et al. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20 (6) :801-9.|[2]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

β-lactam

Available Sizes

Curated Selection

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