PIP-199

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].

Product Specifications

CAS Number

[622795-76-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pip-199.html

Purity

98.0

Solubility

DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC

Molecular Formula

C27H28N4O3

Molecular Weight

456.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Andrew F. Voter, et al. A high throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway. J Biomol Screen. 2016 Jul; 21 (6) : 626–633.