Vofopitant (dihydrochloride)

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1 (NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].

Product Specifications

CAS Number

[168266-51-1]

Product Name Alternative

GR 205171A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/vofopitant-dihydrochloride.html

Purity

99.56

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

COC1=C(CN[C@H]2CCCN[C@H]2C3=CC=CC=C3)C=C(N4N=NN=C4C(F)(F)F)C=C1.[H]Cl.[H]Cl

Molecular Formula

C21H25Cl2F3N6O

Molecular Weight

505.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65 (1) :45-53.