CK0492B
CK0492B is a novel biaminourea antibiotic that has antiplaque properties in vitro and has shown efficacy in an experimental mouse dental disease model. A 12-week study in beagles compared its efficacy in reducing plaque and gingivitis, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease are similar to humans. Chlorhexidine acetate was selected as a positive control for plaque and gingivitis reduction and staining because it is effective in both humans and dogs.
Product Specifications
CAS Number
64169-11-5
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ck0492b.html
Smiles
O=C(NC12CC3CC(C2)CC(C1)C3)NC(NCCCN4CCN(CCCNC(NC(NC56CC7CC(C6)CC(C5)C7)=O)=N)CC4)=N.O=S(O)(C)=O.O=S(O)(C)=O
Molecular Formula
C36H66N10O8S2
Molecular Weight
831.10
References & Citations
[1]Basic Biological Sciences: Effects of Chlorhexidine and Four Antimicrobial Compounds on Plaque, Gingivitis, and Staining in Beagle Dogs
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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