Cedazuridine
Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research[1].
Product Specifications
CAS Number
[1141397-80-9]
Product Name Alternative
E7727
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cedazuridine.html
Purity
99.72
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O[C@H]1C(F)(F)[C@H](N(CC[C@@H](O)N2)C2=O)O[C@@H]1CO
Molecular Formula
C9H14F2N2O5
Molecular Weight
268.21
Precautions
H315, H319, H320
References & Citations
[1]Ferraris D, et al. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27; 57 (6) :2582-8.|[2]Ramsey H E, et al. Oral azacitidine and cedazuridine approximate parenteral azacitidine efficacy in murine model. Targeted Oncology, 2020, 15 (2) : 231-240.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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