Cedazuridine

Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research[1].

Product Specifications

CAS Number

[1141397-80-9]

Product Name Alternative

E7727

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cedazuridine.html

Purity

99.72

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O[C@H]1C(F)(F)[C@H](N(CC[C@@H](O)N2)C2=O)O[C@@H]1CO

Molecular Formula

C9H14F2N2O5

Molecular Weight

268.21

Precautions

H315, H319, H320

References & Citations

[1]Ferraris D, et al. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27; 57 (6) :2582-8.|[2]Ramsey H E, et al. Oral azacitidine and cedazuridine approximate parenteral azacitidine efficacy in murine model. Targeted Oncology, 2020, 15 (2) : 231-240.