VBIT-4

VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

Product Specifications

CAS Number

[2086257-77-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

VDAC

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vbit-4.html

Purity

99.46

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

O=C(NC1=CC=C(Cl)C=C1)CC(CO)N2CCN(C3=CC=C(OC(F)(F)F)C=C3)CC2

Molecular Formula

C21H23ClF3N3O3

Molecular Weight

457.87

Precautions

H315, H319, H335

References & Citations

[1]Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291 (48) :24986-25003.