Y-29794 (tosylate)
Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) [1][2].
Product Specifications
CAS Number
143984-17-2
UNSPSC
12352005
Target
Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/y-29794-tosylate.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C(C)C)N=C1SCCCCCCCCN(C)C)C2=CC=CS2.O=S(C3=CC=C(C)C=C3)(O)=O
Molecular Formula
C30H42N2O4S3
Molecular Weight
590.86
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PREP
Available Sizes
Frequently Asked Questions
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