Aditoprime

Aditoprime (Aditoprim) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics[1][2][3].

Product Specifications

CAS Number

[56066-63-8]

Product Name Alternative

Aditoprim

UNSPSC

12352005

Target

Antifolate; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/aditoprime.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=C(CC2=CC(OC)=C(N(C)C)C(OC)=C2)C(N)=N1

Molecular Formula

C15H21N5O2

Molecular Weight

303.36

References & Citations

[1]Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988;35 (2) :114-120. |[2]Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017;7:41370. Published 2017 Feb 1. |[3]Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015;35 (12) :1531-1538.