FA-Phe-Phe

FA-Phe-Phe is a furylacryloyl (fa) -amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE) . FA-Phe-Phe is also a specific substrate of Cathepsin A[1][2].

Product Specifications

CAS Number

[83661-95-4]

UNSPSC

12352209

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fa-phe-phe.html

Solubility

10 mM in DMSO

Smiles

OC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(/C=C/C2=CC=CO2)=O)CC3=CC=CC=C3)=O)=O

Molecular Formula

C25H24N2O5

Molecular Weight

432.47

References & Citations

[1]Mayer M, et al. Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy. J Med Chem. 2000 Jun 1;43 (11) :2093-9.|[2]Ostrowska H, et al. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Commun. 1997 May 29;234 (3) :729-32.