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Mindeudesivir (hydrobromide)

Mindeudesivir (JT001; VV116; GS-621763-d1) hydrobromide is a deuterated version of Remdesivir , a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19[1][2].

Product Specifications

CAS Number

2779498-79-0

Product Name Alternative

VV116; GS-621763-d1 (hydrobromide)

UNSPSC

12352005

Target

Influenza Virus; RSV; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

98.16

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

[H]Br.N#C[C@](O[C@@H]1COC(C(C)C)=O)(C2=CC([2H])=C3N2N=CN=C3N)[C@@H]([C@@H]1OC(C(C)C)=O)OC(C(C)C)=O

Molecular Formula

C24H31DBrN5O7

Molecular Weight

583.45

References & Citations

[1]Zhang R, et al. Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model. Signal Transduct Target Ther. 2022;7 (1) :123. Published 2022 Apr 16.|[2]Qian HJ, et al. Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects [published online ahead of print, 2022 Mar 16]. Acta Pharmacol Sin. 2022;1-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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