Rabbit Anti-Human, Rat CD326 Polyclonal Antibody

CD326 functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. CD326 mediates Ca2+-independent homotypic interactions. Formation of CD326-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. CD326 is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. CD326 is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types.