TP-021
TP-021 (BCL6-IN-8c), a chemical probe, is a potent and orally active B-cell lymphoma 6 (BCL6) -corepressor interaction inhibitor with an IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay[1].
Product Specifications
CAS Number
[2130878-25-8]
Product Name Alternative
BCL6-IN-8c
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tp-021.html
Concentration
10mM
Purity
99.14
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1NC2=C(CC1)C=C(C=C2)NC3=CC(OC4CCOCC4)=C(C=C3Cl)[N+]([O-])=O
Molecular Formula
C20H20ClN3O5
Molecular Weight
417.84
References & Citations
[1]Yasui T, et al. Discovery of a novel B-cell lymphoma 6 (BCL6) -corepressor interaction inhibitor by utilizing structure-based drug design. Bioorg Med Chem. 2017 Sep 1;25 (17) :4876-4886.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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