Histone Acetyltransferase Inhibitor II
Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells[1].
Product Specifications
CAS Number
932749-62-7
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Histone-Acetyltransferase-Inhibitor-II.html
Concentration
10mM
Purity
98.70
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1/C(CCC/C1=C\C2=CC=C(O)C(Br)=C2)=C/C3=CC=C(O)C(Br)=C3
Molecular Formula
C20H16Br2O3
Molecular Weight
464.15
Precautions
H315, H319
References & Citations
[1]Costi R, et al. Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase. J Med Chem. 2007 Apr 19;50 (8) :1973-7. Epub 2007 Mar 10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; TIP60
Available Sizes
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