Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Liarozole (hydrochloride)

Liarozole hydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA) . Liarozole hydrochloride inhibits the cytochrome P450 (CYP26) -dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole hydrochloride shows antitumoral properties[1][2][3].

Product Specifications

CAS Number

145858-50-0

Product Name Alternative

R75251 (hydrochloride)

UNSPSC

12352005

Target

Cytochrome P450; RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/liarozole-hydrochloride.html

Smiles

ClC1=CC(C(C2=CC=C3N=CNC3=C2)N4C=CN=C4)=CC=C1.Cl

Molecular Formula

C17H14Cl2N4

Molecular Weight

345.23

References & Citations

[1]Kuijpers AL, et al. The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin. Br J Dermatol. 1998;139 (3) :380-389.|[2]Lucker GP, et al. Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liarozole. Br J Dermatol. 1997;136 (1) :71-75.|[3]Wouters W, et al. Effects of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. Cancer Res. 1992;52 (10) :2841-2846.|[4]Pignatello MA, et al. Liarozole markedly increases all trans-retinoic acid toxicity in mouse limb bud cell cultures: a model to explain the potency of the aromatic retinoid (E) -4-[2- (5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylenyl) -1-propenyl] benzoic acid. Toxicol Appl Pharmacol. 2002; 178 (3) :186-194.|[5]Van Wauwe J, et al. Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J Pharmacol Exp Ther. 1992;261 (2) :773-779.|[6]Stearns ME, et al. Liarozole and 13-cis-retinoic acid anti-prostatic tumor activity [published correction appears in Cancer Res 1993 Dec 1;53 (23) :5831]. Cancer Res. 1993;53 (13) :3073-3077.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Mosapride N-Oxide
TRC-M731015-5MG 5 mg

Mosapride N-Oxide

Sign In for Pricing
View Details
Tissue FFPE Sections, Endometrium
CS805523 5x 5 µm

Tissue FFPE Sections, Endometrium

Sign In for Pricing
View Details
CD79b (B-Cell Marker) (IGB/2940R), CF647 conjugate, 0.1mg/mL
BNC472940-500 1x 500 µL

CD79b (B-Cell Marker) (IGB/2940R), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Barbital-d5
TRC-B118502-10MG 10 mg

Barbital-d5

Sign In for Pricing
View Details
PSMA (FOLH1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2E1]
TA504509BM 100 µL

PSMA (FOLH1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2E1]

Sign In for Pricing
View Details
Creatine kinase M type (CKM) (NM_001824) Human Over-expression Lysate
LC400690 20 µg

Creatine kinase M type (CKM) (NM_001824) Human Over-expression Lysate

Sign In for Pricing
View Details