8α,9α-Epoxycoleon-U-quinone
Product Specifications
UNSPSC Description
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX[1].
Target Antigen
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8α-9α-epoxycoleon-u-quinone.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@]1(O[C@@]213)C(C(O)=C4[C@@]2(CCCC(C)4C)C)=O)C(C(C)C)=C(O)C3=O
Molecular Weight
360.40
References & Citations
[1]Ntungwe EN, et al. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022 Mar 11;13(4):674-680.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10564/8α-9α-Epoxycoleon-U-quinone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10564/
Clinical Information
No Development Reported
CAS Number
93800-59-0
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