8α,9α-Epoxycoleon-U-quinone

Product Specifications

CAS Number

[93800-59-0]

UNSPSC Description

8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX[1].

Target Antigen

P-glycoprotein

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8α-9α-epoxycoleon-u-quinone.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@]1(O[C@@]213)C(C(O)=C4[C@@]2(CCCC(C)4C)C)=O)C(C(C)C)=C(O)C3=O

Molecular Weight

360.40

References & Citations

[1]Ntungwe EN, et al. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022 Mar 11;13(4):674-680.