MIND4-19
MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. MIND4-19 can be used for researching Huntington's disease[1].
Product Specifications
CAS Number
129544-85-0
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mind4-19.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C1(COC2=CC=CC=C2)=NN=C(SCC3=CC=CC=C3)N1C4=CC=CC=C4
Molecular Formula
C22H19N3OS
Molecular Weight
373.47
Precautions
H315, H319
References & Citations
[1]Quinti L, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chem Biol. 2016 Jul 21;23 (7) :849-861.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT2