WAAG-3R
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay[1][2]. (Ex/Em = 340/420 nm)
Product Specifications
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/waag-3r.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC([N+]([O-])=O)=CC=C1NC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(C2=C(C=CC=C2)N)=O)[C@@H](C)O)=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)C)=O)CCCNC(N)=N)=O)=O)CO)=O)C(C)C)=O)[C@H](CC)C)=O)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCCN)=O)[O-]
Molecular Formula
C69H109N23O24
Molecular Weight
1644.74
References & Citations
[1]De Savi C, et al. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis[J]. Bioorganic & medicinal chemistry letters, 2011, 21 (5) : 1376-1381.|[2]Hongfeng Deng, et al. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT) . J Med Chem. 2012 Aug 23;55 (16) :7061-79.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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