H117
H117 is a PROTAC target protein ligand that can be used to synthesize PROTAC HP211206. H117 has competitive binding and inhibition ability on SARS-CoV-2 main protease (Mpro) with an IC50 of 151.3 nM[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; PROTAC
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/h117.html
Purity
99.27
Smiles
O=C(N1[C@H](C(N[C@H](C#N)C[C@H]2C(NCC2)=O)=O)C[C@@H](OC(F)F)C1)[C@H](C(C)(C)C)NC(OC(C)(C)C)=O
Molecular Formula
C24H37F2N5O6
Molecular Weight
529.58
References & Citations
[1]Sang X, et al. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells. J Am Chem Soc. 2023 Dec 20;145 (50) :27248-27253.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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