SIAIS630121-NC
SIAIS630121-NC is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) degrader SIAIS630121 (Sturcture Note: (Blue: Cereblon ligand Thalidomide (HY-14658) analogue (HY-138793), Black: linker; Pink: Nampt inhibitor FK866 (HY-50876) ) [1].
Product Specifications
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/siais630121-nc.html
Smiles
O=C(NCCCCC1CCN(C(C2=CC=C(N3CCN(CCCCCCC#CC4=CC=CC5=C4CN(C(CC6)C(N(C)C6=O)=O)C5=O)CC3)C=C2)=O)CC1)/C=C/C7=CC=CN=C7
Molecular Formula
C50H61N7O5
Molecular Weight
840.06
References & Citations
[1]Xiaotong Zhu, et al. Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation.Cell Chem Biol
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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