SIAIS630121-NC

SIAIS630121-NC is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) degrader SIAIS630121 (Sturcture Note: (Blue: Cereblon ligand Thalidomide (HY-14658) analogue (HY-138793), Black: linker; Pink: Nampt inhibitor FK866 (HY-50876) ) [1].

Product Specifications

UNSPSC

12352005

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/siais630121-nc.html

Smiles

O=C(NCCCCC1CCN(C(C2=CC=C(N3CCN(CCCCCCC#CC4=CC=CC5=C4CN(C(CC6)C(N(C)C6=O)=O)C5=O)CC3)C=C2)=O)CC1)/C=C/C7=CC=CN=C7

Molecular Formula

C50H61N7O5

Molecular Weight

840.06

References & Citations

[1]Xiaotong Zhu, et al. Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation.Cell Chem Biol

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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