Rupatadine (Fumarate)

Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria[1][2][3].

Product Specifications

CAS Number

[182349-12-8]

Product Name Alternative

UR-12592 (Fumarate)

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Autophagy; Histamine Receptor

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Rupatadine-Fumarate.html

Purity

99.99

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1.O=C(O)/C=C/C(O)=O

Molecular Formula

C30H30ClN3O4

Molecular Weight

532.03

Precautions

H302, H413

References & Citations

[1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF) . J Pharmacol Exp Ther. 1997 Jan;280 (1) :114-21.|[2]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49 (7) :355-60.|[3]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8 (7) :e68631.