NA-1-157

NA-1-157 is a potent irreversible covalent inhibitor of the GES-5 carbapenemase, with a MIC of 0.5 μg/mL[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/na-1-157.html

Solubility

10 mM in DMSO

Smiles

C[C@]1([C@H]2[C@H](O)C)CC(S[C@@H]3CC(C(N(C)C)=O)NC3)=C(C(O)=O)N1C2=O

Molecular Formula

C17H25N3O5S

Molecular Weight

383.46

References & Citations

[1]Nichole K Stewart, et al. Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase. ACS Infect Dis. 2024 Mar 21.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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