EIF4A3-IN-1
EIF4A3-IN-1 is a selective eIF4A3 inhibitor (IC50: 0.26 μM; Kd: 0.043 μM) with cellular nonsense-mediated RNA decay (NMD) inhibitory activity. eIF4A3-IN-1 can specifically bind to the non-ATP binding site of eIF4A3. eIF4A3-IN-1 has anti-tumor and analgesic activities[1][2][3].
Product Specifications
CAS Number
2095486-67-0
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eif4a3-in-1.html
Purity
99.96
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2
Molecular Formula
C29H23BrClN5O2
Molecular Weight
588.88
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF4
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Eimeria tenella Membrane-associated calcum-binding protein, related, putative, C-His
Recombinant Eimeria tenella Membrane-associated calcum-binding protein, related, putative, C-His
Recombinant Eimeria tenella Membrane-associated calcum-binding protein, related, putative, C-His
CIDEB (Cell Death-inducing DFFA-like effector b) (MaxLight 550)
