Virginiamycin S1

Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections[1][2].

Product Specifications

CAS Number

[23152-29-6]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/virginiamycin-s1.html

Purity

99.13

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@](CC(CC2)=O)([H])C(N[C@@H](C3=CC=CC=C3)C(O[C@@H]([C@H](NC(C4=C(C=CC=N4)O)=O)C(N[C@H](CC)C(N5[C@](CCC5)([H])C(N(C)[C@H]1CC6=CC=CC=C6)=O)=O)=O)C)=O)=O

Molecular Formula

C43H49N7O10

Molecular Weight

823.89

References & Citations

[1]Ningsih F, et al. VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine. Microbiology. 2011 Nov;157 (Pt 11) :3213-20.|[2]Ge B, et al. Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae. Sci Rep. 2017 Sep 8;7 (1) :11017.